Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
China's expenditure on technology research and development rose 10.6% to 1.57 trillion yuan in 2016, the fastest annual growth since 2014, as the nation increases its investment in new driving forces to stabilize the economy.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The dollar value of exports from emerging market countries will rise next year for the first time since 2014, helped by higher commodity prices and modestly stronger demand, it is predicted.
客户通过Twitter 和Faceboo向世界传播“糟糕经历”的能力已经改变了客服世界的生态。尼尔森公司(Nielsen)2012年的一项调查显示，超过一半的客户现在通过社交媒体寻求补救措施；与此同时，在Twitter上提出问题或抱怨后，大约81%的用户提出当天就能获得回应。但在今年秋天，事情变得更加有趣：9月2日，英国航空公司(British Airways)乘客赛义德?哈桑斥资大约1,000美元，购买了几条“推广消息”，猛烈抨击这家航空公司弄丢了他的行李。鉴于有偿社交媒体推广现已成为客户的新武器，从2014年开始，各大航空公司、信用卡公司、银行和其他累犯提供的糟糕透顶的客户服务或将走向终结。无穷无尽的电话等待时间和那些自动化的“电话树”（比如，“英语服务请按1，西班牙语服务请按2，您整整一个下午都需要等候接听请按3”）或许将被扔入历史的垃圾桶。
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
That feeling of success may have provided a sort of identity in itself.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Businesses can benefit in other ways too. Craig Rollason, business analysis manager at National Grid, says he has improved his coaching skills by mentoring a Teach Firster.
Marvel created superhero Blue Ear, who wears a hearing aid, after a little boy refused to wear one because "superheroes don’t wear hearing aids".
Attraction: The adventure of a lifetime
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
The research comes at a time of increasing anti-China rhetoric in US politics, and ahead of three politically sensitive anti-dumping cases this summer against Chinese steel imports that could result in the US imposing punitive duties of as much as 500 per cent.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
This movie tells the story of Wade Wilson, played by Ryan Reynolds, who is a mercenary with accelerated healing powers and a dark sense of humour. He's now on the lookout for the man who almost destroyed his life by subjecting him to rogue experiments. Deadpool belongs to the Marvel Universe and is their most unconventional anti-hero.
ACE2 as a potential therapeutic target for pandemic COVID-19
Wang studied computer programming while growing up in China. After college, she hoped to move to the U.S. to start her career. The next year, the Chinese Students Protection Act was passed and Wang got her master's in computer science at University of Houston. She worked at several Silicon Valley startups (and launched her own, iBizWomen.com) until September 11, 2001. The attack inspired her to create Binary Group, a technology consulting company that works with the Federal Government. Over the past 16 years, Binary has helped its clients save piles of money -- like the Army 20th Support Command, which cut $60 million over five years for its satellite communication bandwidth requirements.
Diagnostic technologies for COVID-19: a review
Making Airbnb go away might not be so easy. A recent Quinnipiac poll found that 56 percent of the responders thought New Yorkers should be allowed to rent rooms out to strangers. “We don’t want to turn into hotels, but at the same time people want to rent out their apartments sometimes,” said Paul R. Gottsegen, the president of Halstead Management Company, which manages 250 residential properties in the city.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The values of the citizenry are a democracy’s most important asset.
●"Florida man dies in meth-lab explosion after lighting farts on fire"
其他数个政党的支持率只是略低于上述两党，包括持中间立场的自由派政党民主66 (D66)、基督教民主联盟(Christian Democratic Appeal)和左翼的绿色左翼党(GreenLeft)。
Having said this, don't make a pest of yourself. Nobody wants to hear you ask a question every 10 minutes. If you're completely lost, make an appointment to see your teacher after class.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Personal per capita disposable income increased by 6.3 percent in real terms.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Average age: 33 in Philadelphia, 36 in San Francisco
Antiviral drug discovery: broad-spectrum drugs from nature
The two pleasure devices both made of bronze date back more than 2000 years to China's Han Dynasty (206 BC–220 AD).
Influenza neuraminidase: A druggable target for natural products
'For now she wears a dab of lipstick and nail varnish.'
But he told Washington's Observer-Reporter paper that he was keen to read it as it was "a testament of the sincerity, interest and innocence of that time".
The world's first flying bicycle flew on November 9, 1961, when Derek Pigott of the University of Southampton flew in a bicycle with an airplane-like body. It was called the Southampton University Man Powered Aircraft (sumpac). Derek furiously pedaled the air-bike to get it off the ground. It then flew 1.8 meters (about 6 ft) above the ground over a distance of 64 meters (210 ft). While the flight was short and slow, it still does not change the fact that it was the first bicycle to fly and at the same time, the first human-powered flight.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
China is committed to denuclearization of the Korean Peninsula, the peace and stability in the Korean Peninsula, and resolving issues through dialogue and consultation. That is China’s consistent and clear-cut position.
The role of biosensors in the detection of emerging infectious diseases
About 40 per cent of entrepreneurs did not seek any help when securing finance. Half of these raised equity purely from their own savings and/or family and friends compared with only 40 per cent of those who sought help from the school or alumni network.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
With a growing need for someone to block and tackle Apple’s raiders and (given its tax investigation in Europe) regulators, Mr Cook’s focus on people, strategy and execution — rather than products — finally started to look like an advantage.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
"Those who disrupt testing and harm the equity of education by cheating will get the punishment they deserve," the ministry said.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
For over two decades I have been writing about the rise of Asia and the dynamic driving it. There is an extraordinary consensus among east Asian leaders that Asia needs to use this window of opportunity to focus on economic development and growth. War is the biggest obstacle to development. If Asians were truly stupid, they would engage in such wars and derail their enormous development promise. Most Asian leaders, barring North Korea, understand well the dangers of war. Hence, while there will be tensions and rivalries in the region, there will be no wars in the region, in 2014 or in 2015. As 2015 unfolds, I would like to encourage all western pundits to understand the underlying Asian dynamic on its own terms, and not on the basis of western preconceptions.
As for China, lack or stopped development represents the biggest risk for this country. So it is essential that we maintain steady medium-high growth of our economy and that in itself is China’s contribution to global stability.
Inhibition of SARS coronavirus helicase by bismuth complexes
A candidate's age is no gauge of their effectiveness, Sonneborn tells PEOPLE, saying that despite Donald Trump being the oldest person elected to the U.S. Presidency, “He tweets like a kindergartener.”
Arlie Russell Hochschild, the author of “Strangers in Their Own Land: Anger and Mourning on the American Right,” describes a feeling of lost opportunity as the “deep story” of the rural Louisiana communities she spent four years studying.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Like air, blue skies treat everyone equally.
Sales of previously owned homes have slipped every month since July, according to the National Association of Realtors. That coincides with the surge in borrowing costs across the economy as a result of the Fed's signals about its bond-buying program.
Australia is the No. 8 Best Country overall. The Land Down Under – No. 4 in Quality of Life and No. 9 in Adventure – also ranks in the top 10 in terms of education.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
It is the first time that EMBA-Global, the joint programme delivered by London Business School and Columbia Business School, has dropped out of the top five.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
“我去的每一个地方，都发现企业主对未来的需求量有一个很好的预期，” Gus Faucher PNC金融服务机构的资深经济学家称。“商人必须提高薪酬来吸引更多的劳动力或者保留原有的工人”。
Episodic memory is also known as long-term memory, and the researchers approached the study of exercise in a different manner than previous studies. Other studies examined the impact of aerobic exercise conducted over many months, but this study simply asked participants to lift weights a single time. During the test, half of the participants were asked to use a weight machine before recalling a series of images they were shown at the start of the test. The other half of the participants were also asked to recall the images but without having engaged in any strenuous activity before the recall session. In demonstrating the memory improvement for the participants who engaged in just a single session of weight lifting, the researchers were able to show that improving one's memory through exercise didn't take hours of dedication in the gym. The next time you have the opportunity to lift weights or someone tries to convince you to join the gym you might just want to take him or her up on the offer.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Matthew McConaughey and Jared Leto both won for their startlingly gaunt performances in the Texas HIV drama 'Dallas Buyers Club.' Leonardo DiCaprio, a nine-time Golden Globe nominee, won his second Globe for best actor in a comedy for his uninhibited work in 'The Wolf of Wall Street.' He thanked director Martin Scorsese for his mentorship ('Wolf' is their fifth film together) and for 'allowing me to stalk you to make this movie.'
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
201202/172834.shtmlChinese entrepreneur Wang Xing stays in touch with a sister in California and an uncle in Australia through chat software that offers a glimpse of how China's Internet companies can compete globally.
Among the year’s biggest surprises was the plunge in gasoline pries. Economists differed on the economic impact—money in the pockets of consumers offset by declines in exploration and drilling activity—but everyone agreed that it was bearish for small cars and hybrids. The combination of cheap gas and a steep sticker price made the Cadillac ELR the runaway winner of the most disliked car of the year award. Only 155 of the Volt-based $80,000 cars found buyers in November.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
But economists generally expect the momentum of the recent past to resume and continue once storm distortions abate. The 45 economists who responded to The Wall Street Journal's latest monthly forecasting survey saw the jobless rate falling to 7.8% by next June and 7.5% by the end of 2013. Some say job growth could accelerate from its slow pace. 'I think businesses are going to have to hire,' said Bob Baur, an economist with Principal Global Investors.[qh]
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Prince Miteb bin Abdullah, one of the most senior Saudi royals detained in the kingdom's corruption crackdown, has been released after reaching a settlement deal believed to exceed the equivalent of $1 billion, an official involved in the anti-graft campaign said.
Fudan University and Peking University, two prestigious comprehensive universities in China, were ranked fourth and sixth on the salary ranking, while the remaining of the top 20 were dominated by finance/economics and science/technology schools.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The EU’s Americas gambits
The drama got 7.2 points on Douban, receiving criticism for having too much romance and too few of Zhou's struggles.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
在假日旅行最佳航空公司的排行榜上，夏威夷航空公司（Hawaiian Airlines）遥遥领先，紧随其后的是另一家主要经营太平洋海岸业务的阿拉斯加航空公司（Hawaiian Airlines）。相反，根据FlightAware的数据显示，假日旅行期间最差的航空公司是总部位于纽约的捷蓝航空公司（JetBlue Airways），经营区域航线的快捷航空（ExpressJet）排名倒数第二。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
你可能觉得我们对于列清单的爱好是从“十诫”继承而来，但安伯托·艾柯( Umberto Eco)的说法却正相反，“清单是文化的起源”，他写过一本书，《无限的清单》(The Infinity of Lists)，书中在讨论自己熟悉的东西时这样说道。而且，文化希望“让无限变得可以理解”，并且“创造秩序——不是永远如此，但通常都是这样”，所以才有了荷马在《伊利亚特》中的人名清单，以及你冰箱上贴着的，永远做不完的家务清单。“我们喜欢清单，因为我们不想死，”艾柯还说，这可能是对“清单体”(listicle)的最佳解释了。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
200911/88512.shtmlA love letter to a US college student from the girlfriend who was to become his wife is finally on its way to him - 53 years after it was written in 1958.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
She is now so successful that her mother has hired a security team who monitor the star 24/7.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Of course, these same new forces may also trigger a backlash and a reversion to old command-and-control ways of leading. The politicians who dominate the world stage are, depressingly, mostly cut from the old cloth, and the leadership challenges they face, from Brexit to North Korea, are particularly complex.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Yes, some molds cause allergic reactions and respiratory problems. And a few molds, in the right conditions, produce "mycotoxins," poisonous substances that can make you sick.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
As we pointed out earlier, we've long been able to restore hearing to the deaf, but restoring sight to the blind is a much more complicated matter. When people lose their sight, their retinas no longer send signals from their photoreceptors to their brains. To make an artificial eye, we'd need to understand how the retina processes those signals, and that's a code scientists just haven't been able to crack.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
An escalating war on drugs in the Philippines has led to almost 1,800 deaths under new president Rodrigo Duterte, the country’s police chief has said.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
On Monday the research team said the skeleton confirmed that the monarch had severe scoliosis, or twisting of the spine. It may have been painful and caused his right shoulder to appear higher than his left, but there was no evidence of the withered arm depicted in Shakespeare's "Richard III".
A facile assay for rapid detection of COVID-19 antibodies
9．The Bling Ring
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Australia is the No. 8 Best Country overall. The Land Down Under – No. 4 in Quality of Life and No. 9 in Adventure – also ranks in the top 10 in terms of education.
6. China will also soonmake further announcements regarding affordable housing and more accessiblehealthcare. The country still needs 75 million more $75,000 housing unitsand it will begin breaking ground on them, in earnest, in 2014. Theseinvestments, particularly in health care, will effectively become self-funded,allowing average Chinese consumers to consider saving less, and spending more. It will drive longevity and years of productive employment.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Best chances: Best film and best director. Surprisingly, Nolan has never received a directing nomination from the Academy.
Format: Alternating Friday-Saturday classes, with an initial week-long meeting and a week-long international study seminar
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Specifically, the SAPPRFT said the total box office of China in 2016 reached 45.7 billion yuan (around 6.6 billion USD), an increase of 3.7 percent over 2015.
The fruit is placed into the mold when it's young and undeveloped.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
*最佳综艺节目台本创作：《约翰?奥利佛上周今夜秀》(Last Week Tonight With John Oliver)
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Critics have been eager to point out that he is not so closely involved in new product development as his predecessor, and fails to elicit the same excitement when he takes to the stage to introduce them. But Mr Cook is aware of his shortcomings and has drawn on the worlds of fitness and fashion to assemble a new team of talents, including Angela Ahrendts, formerly of Burberry, and industrial designer Marc Newson.
Anti-HIV drug repurposing against SARS-CoV-2
“It’s fundamentally about ‘who are we?’” said Eric Kaufmann, a professor of politics at Birkbeck College, University of London. “What does it mean to be part of this nation? Is it not ‘our’ nation anymore, ‘our’ meaning the ethnic majority?
Length-scale dependence of protein hydration-shell density
“…was snervous she almost fainted.”
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
13. iPhone 提醒
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Did I mention that LeBron James is a free agent this summer?
About this collection
After year of stars such as Salma Hayek and Gwyneth Paltrow claiming to be vistims of harassment, McGowan has said she understands why Donald Trump supporters hate Hollywood, whose apparent liberalism she says is fake.
But the best answer to the Oscar statue display question comes from Timothy Hutton, the youngest person ever to win the Academy Award for best supporting actor. Hutton, who won the gold figurine for his role in Ordinary People, was apparently having a party a number of years ago. His sister popped the Oscar in the fridge alongside the beers so that guests would happen upon it en route to refreshment. The statue is apparently still in there.